Association of CYP2D6*4 genetic polymorphism on the metabolism of Donepezil with Alzheimer's disease in Indian population
نویسندگان
چکیده
Background Alzheimer’s disease (AD) is the most common adult form of dementia.1 It is an age-associated neurodegenerative disorder pathologically characterized by the abnormal accumulation of intracellular neurofibrillary tangles and extra cellular amyloid plaques in selected brain regions. Donepezil is a cholinesterase inhibitor currently being used in the treatment of Alzheimer’s disease is metabolized via CYP2D6 enzymes. The present study was undertaken to investigate CYP2D6*4 polymorphism on the serum concentration of Donepezil with responders and non-responders to Alzheimer’s patients.
منابع مشابه
The non-functional polymorphism in CYP2D6 gene (CYP2D6*4): Report of frequency and assessment of CYP2D6*4 association with response to atorvastatin, in patients with high LDL level in North of Iran, Guilan Province
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